|
Record |
Links |
|
Author |
Nirma, C.; Rodrigues, A.M.S.; Basset, C.; Chevolot, L.; Girod, R.; Moretti, C.; Stien, D.; Dusfour, I.; Eparvier, V. |
|
|
Title |
Larvicidal activity of isoflavonoids from Muellera frutescens extracts against Aedes aegypti |
Type |
Journal Article |
|
Year |
2012 |
Publication |
Natural Product Communications |
Abbreviated Journal |
|
|
|
Volume |
7 |
Issue |
10 |
Pages |
1319-1322 |
|
|
Keywords |
Aedes aegypti; French Guiana; Insecticides; Isoflavonoids; Muellera frutescens |
|
|
Abstract |
The biological activity of extracts from the leaves, bark and roots of Muellera frutescens, an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides. The n-hexane extracts of bark, leaf, and root showed a strong toxic activity against Aedes aegypti mosquito larvae. Bioguided fractionation of the bark extract led to the isolation of seven isoflavonoids (12a-hydroxyelliptone, elliptone, (-)-variabilin, rotenone, rotenolone, tephrosin and deguelin). Rotenone and deguelin are responsible for the larvicidal activity of the plant. M. frutescens leaves contain up to 0.6%, w/w, deguelin. These results justify the traditional ichtyotoxic use of M. frutescens. The leaves contain a relatively high proportion of deguelin and, therefore, can be considered as a renewable source of this environmentally friendly insecticidal isoflavonoid. |
|
|
Address |
CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette, France |
|
|
Corporate Author |
|
Thesis |
|
|
|
Publisher |
|
Place of Publication |
|
Editor |
|
|
|
Language |
|
Summary Language |
|
Original Title |
|
|
|
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
|
Series Volume |
|
Series Issue |
|
Edition |
|
|
|
ISSN |
|
ISBN |
|
Medium |
|
|
|
Area |
|
Expedition |
|
Conference |
|
|
|
Notes |
Export Date: 6 December 2012; Source: Scopus |
Approved |
no |
|
|
Call Number |
EcoFoG @ webmaster @ |
Serial |
448 |
|
Permanent link to this record |