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Cachet, N.; Ho-A-Kwie, F.; Rivaud, M.; Houel, E.; Deharo, E.; Bourdy, G.; Jullian, V. |
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Title |
Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae) |
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Journal Article |
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Year |
2012 |
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Phytochemistry Letters |
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Phytochem. Lett. |
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5 |
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1 |
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162-164 |
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Keywords |
Malaria; P. falciparum; Quassia amara; Quassinoids; Simaroubaceae |
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Abstract |
A new quassinoid Picrasin K 1 was isolated from a decoction made of Quassia amara leaves, traditionally used in French Guyana to treat malaria. The structure and relative stereochemistry of 1 was determined through extensive NMR analysis. Picrasin K showed a low activity against Plasmodium falciparum in vitro (IC 50 = 8 μM), and a similar low activity on human cancerous cells line (IC 50 = 7 μM on MCF-7 cells line). © 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
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CNRS, UMR Ecofog, Université des Antilles et de la Guyane, Cayenne, France |
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18743900 (Issn) |
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Notes |
Export Date: 8 March 2012; Source: Scopus; doi: 10.1016/j.phytol.2011.12.001; Language of Original Document: English; Correspondence Address: Jullian, V.; UMR-152 Pharma-Dev, IRD, Université Paul Sabatier Toulouse 3, 31062 Toulouse, France; email: jullian@cict.fr |
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EcoFoG @ webmaster @ |
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382 |
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