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Author  |
Bertani, S.; Houel, E.; Stien, D.; Chevolot, L.; Jullian, V.; Garavito, G.; Bourdy, G.; Deharo, E. |
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Title |
Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara L. (Simaroubaceae) |
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Journal Article |
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Year |
2006 |
Publication |
Journal of Ethnopharmacology |
Abbreviated Journal |
J. Ethnopharmacol. |
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Volume |
108 |
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1 |
Pages |
155-157 |
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Keywords |
antimalarial; Quassia amara; quassinoids; simalikalactone D; traditional medicine |
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Abstract |
French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10 nM against FeB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea. (c) 2006 Elsevier Ireland Ltd. All rights reserved. |
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Address |
Univ Toulouse 3, UMR 152, Ctr IRD, F-97323 Cayenne, French Guiana, Email: deharo@cayenne.ird.fr |
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Publisher |
ELSEVIER IRELAND LTD |
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ISSN |
0378-8741 |
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Notes |
ISI:000241573000023 |
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Call Number |
EcoFoG @ eric.marcon @ |
Serial |
173 |
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