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Nirma, C.; Eparvier, V.; Stien, D. |
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Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a nasutitermes sp. termite |
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Journal Article |
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2013 |
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Journal of Natural Products |
Abbreviated Journal |
J. Nat. Prod. |
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76 |
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5 |
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988-991 |
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Defense mutualisms between social insects and microorganisms have been described in the literature. The present article describes the discovery of a Pseudallescheria boydii strain isolated from Nasutitermes sp. The microbial symbiont produces two antifungal metabolites: tyroscherin and N-methyltyroscherin, a compound not previously described in the literature. Methylation of tyroscherin has confirmed the structure of N-methyltyroscherin. Both compounds are effective antifungal agents with favorable selectivity indices for Candida albicans and Trichophyton rubrum. © 2013 The American Chemical Society and American Society of Pharmacognosy. |
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UMR Ecofog, Institut Pasteur de la Guyane, Université des Antilles et de la Guyane, 23 Avenue Pasteur, 97306 Cayenne, France |
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01633864 (Issn) |
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Export Date: 6 June 2013; Source: Scopus; Coden: Jnprd; :doi 10.1021/np4001703; Language of Original Document: English; Correspondence Address: Eparvier, V.; CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France; email: veronique.eparvier@icsn.cnrs-gif.fr |
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EcoFoG @ webmaster @ |
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491 |
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Nirma, C.; Eparvier, V.; Stien, D. |
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Title |
Reactivation of antibiosis in the entomogenous fungus Chrysoporthe sp. SNB-CN74 |
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Journal Article |
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2015 |
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Journal of Antibiotics |
Abbreviated Journal |
Journal of Antibiotics |
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68 |
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9 |
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586-590 |
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Chrysoporthe sp. SNB-CN74 was isolated from a Nasutitermes corniger nest, and its ethyl acetate extract was found to exhibit very strong antibacterial activity. Two antibacterial metabolites were isolated, (-)-R-skyrin (2) and (+)-rugulosin A (3). Eventually, the fungus lost its antibiotic potential when subcultured, and the use of yeast extract induced the re-expression of these two antibiotics. Yeast extract possibly activated a cryptic pathway by mimicking the presence of an ecological competitor. © 2015 Japan Antibiotics Research Association All rights reserved. |
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Sorbonne Universités, Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique, Banyuls-sur-mer, France |
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Export Date: 12 October 2015 |
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EcoFoG @ webmaster @ |
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628 |
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Nirma, C.; Rodrigues, A.M.S.; Basset, C.; Chevolot, L.; Girod, R.; Moretti, C.; Stien, D.; Dusfour, I.; Eparvier, V. |
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Title |
Larvicidal activity of isoflavonoids from Muellera frutescens extracts against Aedes aegypti |
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Journal Article |
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2012 |
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Natural Product Communications |
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7 |
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10 |
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1319-1322 |
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Aedes aegypti; French Guiana; Insecticides; Isoflavonoids; Muellera frutescens |
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The biological activity of extracts from the leaves, bark and roots of Muellera frutescens, an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides. The n-hexane extracts of bark, leaf, and root showed a strong toxic activity against Aedes aegypti mosquito larvae. Bioguided fractionation of the bark extract led to the isolation of seven isoflavonoids (12a-hydroxyelliptone, elliptone, (-)-variabilin, rotenone, rotenolone, tephrosin and deguelin). Rotenone and deguelin are responsible for the larvicidal activity of the plant. M. frutescens leaves contain up to 0.6%, w/w, deguelin. These results justify the traditional ichtyotoxic use of M. frutescens. The leaves contain a relatively high proportion of deguelin and, therefore, can be considered as a renewable source of this environmentally friendly insecticidal isoflavonoid. |
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CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette, France |
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Export Date: 6 December 2012; Source: Scopus |
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EcoFoG @ webmaster @ |
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448 |
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Nixon, S.; Agwa, A.; Robinson, S.; Walker, A.; Touchard, A.; Schroeder, C.; Vetter, I.; Kotze, A.C.; Herzig, V.; King, G.F. |
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Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activity |
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Journal Article |
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2020 |
Publication |
Toxicon |
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Toxicon |
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177 |
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1 |
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S60 |
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The Institute for Molecular Bioscience, The University of Queensland, Australia; CSIRO Agriculture and Food, Australia; CNRS, UMR Ecologie des forêts de Guyane, France |
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NLM (Medline) |
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18793150 (Issn) |
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EcoFoG @ webmaster @ |
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973 |
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Nixon, Samantha A. ; Robinson, Samuel D. ; Agwa, Akello, J. ; Walker, Andrew A. ; Choudhay, Shivani ; Touchard, Axel ; Undheim, Eivind A.B. ; Robertson, Alan ; Vetter, Irina ; Schroeder, Christina I. ; Kotze, Andrew C. ; Herzig, Volker ; King, Glenn F. |
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Multipurpose peptides: The venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities |
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Journal Article |
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Year |
2021 |
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Biochemical Pharmacology |
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192 |
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114693 |
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In the face of increasing drug resistance, the development of new anthelmintics is critical for controlling nematodes that parasitise livestock. Although hymenopteran venom toxins have attracted attention for applications in agriculture and medicine, few studies have explored their potential as anthelmintics. Here we assessed hymenopteran venoms as a possible source of new anthelmintic compounds by screening a panel of ten hymenopteran venoms against Haemonchus contortus, a major pathogenic nematode of ruminants. Using bioassay-guided fractionation coupled with liquid chromatography-tandem mass spectrometry, we identified four novel anthelmintic peptides (ponericins) from the venom of the neotropical ant Neoponera commutata and the previously described ponericin M−PONTX−Na1b from Neoponera apicalis venom. These peptides inhibit H. contortus development with IC50 values of 2.8–5.6 μM. Circular dichroism spectropolarimetry indicated that the ponericins are unstructured in aqueous solution but adopt α-helical conformations in lipid mimetic environments. We show that the ponericins induce non-specific membrane perturbation, which confers broad-spectrum antimicrobial, insecticidal, cytotoxic, hemolytic, and algogenic activities, with activity across all assays typically correlated. We also show for the first time that ponericins induce spontaneous pain behaviour when injected in mice. We propose that the broad-spectrum activity of the ponericins enables them to play both a predatory and defensive role in neoponeran ants, consistent with their high abundance in venom. This study reveals a broader functionality for ponericins than previously assumed, and highlights both the opportunities and challenges in pursuing ant venom peptides as potential therapeutics. |
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Elsevier |
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EcoFoG @ webmaster @ |
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1031 |
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Ntawuhiganayo, E.B.; Uwizeye, F.K.; Zibera, E.; Dusenge, M.E.; Ziegler, C.; Ntirugulirwa, B.; Nsabimana, D.; Wallin, G.; Uddling, J. |
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Title |
Traits controlling shade tolerance in tropical montane trees |
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Journal Article |
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2020 |
Publication |
Tree physiology |
Abbreviated Journal |
Tree Physiol. |
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40 |
Issue |
2 |
Pages |
183-197 |
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biomass allocation; leaf temperature; plant traits; Rwanda; shade intolerance; shade tolerance; tropical montane forest; article; biomass allocation; breathing; canopy; carbon balance; compensation; photosynthesis; plant leaf; plant stem; rain forest; Rwanda; shade tolerance; species difference; sweating |
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Tropical canopies are complex, with multiple canopy layers and pronounced gap dynamics contributing to their high species diversity and productivity. An important reason for this complexity is the large variation in shade tolerance among different tree species. At present, we lack a clear understanding of which plant traits control this variation, e.g., regarding the relative contributions of whole-plant versus leaf traits or structural versus physiological traits. We investigated a broad range of traits in six tropical montane rainforest tree species with different degrees of shade tolerance, grown under three different radiation regimes (under the open sky or beneath sparse or dense canopies). The two distinct shade-tolerant species had higher fractional biomass in leaves and branches while shade-intolerant species invested more into stems, and these differences were greater under low radiation. Leaf respiration and photosynthetic light compensation point did not vary with species shade tolerance, regardless of radiation regime. Leaf temperatures in open plots were markedly higher in shade-tolerant species due to their low transpiration rates and large leaf sizes. Our results suggest that interspecific variation in shade tolerance of tropical montane trees is controlled by species differences in whole-plant biomass allocation strategy rather than by difference in physiological leaf traits determining leaf carbon balance at low radiation. © The Author(s) 2019. Published by Oxford University Press. |
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Rwanda Agriculture and Animal Resources Development, PO Box 5016Kigali, Rwanda |
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NLM (Medline) |
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17584469 (Issn) |
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Export Date: 16 March 2020 |
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EcoFoG @ webmaster @ |
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922 |
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Ntienoue, J.K.; Reguer, A.; Robert, F.; Nait-Rabah, O.; Roos, C. |
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Electrochemical behaviour of a super austenitic stainless steel in amazonian aqueous environment |
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Journal Article |
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2013 |
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International Journal of Electrochemical Science |
Abbreviated Journal |
Int.J.Electrochem.Sci. |
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8 |
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4 |
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4761-4775 |
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Cyclic voltammetry; Eis; Esem; Passive films; Stainless steel |
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The electrochemical behaviour of 254 SMO super austenitic stainless steel in natural seawater collected from river mouth of French Guiana was investigated. A comparative study of samples immersed during 22 days in this environment was made including influences of scraped biofilm introduced in experiments and of stirring. Electrochemical measurements – open circuit potential (OCP), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and linear polarisation (LP) – are used to characterize the metal/medium interface included biofilms adhesion. The EDX analysis (EDAX system) shows that the chemical composition of adhered biofilm consists mostly of iron, oxygen, silicon and aluminium and seem preferentially bind on metal defects. © 2013 by ESG. |
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Laboratoire Matériaux et Molécules en Milieu Amazonien, Université des Antilles et de la Guyane, UAG-UMR ECOFOG, Campus Trou Biran, Cayenne 97337, French Guiana |
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14523981 (Issn) |
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Export Date: 24 April 2013; Source: Scopus; Language of Original Document: English; Correspondence Address: Roos, C.; Laboratoire Matériaux et Molécules en Milieu Amazonien, Université des Antilles et de la Guyane, UAG-UMR ECOFOG, Campus Trou Biran, Cayenne 97337, French Guiana; email: christophe.roos@guyane.univ-ag.fr |
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EcoFoG @ webmaster @ |
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483 |
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Odonne, G.; Berger, F.; Stien, D.; Grenand, P.; Bourdy, G. |
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Treatment of leishmaniasis in the Oyapock basin (French Guiana): A K.A.P. survey and analysis of the evolution of phytotherapy knowledge amongst Wayãpi Indians |
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Journal Article |
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2011 |
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Journal of Ethnopharmacology |
Abbreviated Journal |
J. Ethnopharmacol. |
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137 |
Issue |
3 |
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1228-1239 |
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Camopi River; French Guiana; Intercultural exchanges; K.A.P.; Knowledge attitude and practices; Knowledge evolution; Leishmaniasis; Oyapock River; Quantitative ethnopharmacology; Teko; Traditional remedies; Wayãpi |
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Ethnopharmacological relevance: Cutaneous leishmaniasis is a neglected disease with a high incidence in French Guiana, mainly in the middle and upper Oyapock basin, where Amerindian and some Brazilian people live. The main goals of this work were (i) to assess the knowledge about leishmaniasis in the different populations of the middle and upper Oyapock basin, (ii) to study the therapeutic strategies adopted by people affected by leishmaniasis and (iii) to document the use of phytotherapeutic remedies for leishmaniasis. Knowledge, attitudes and practices (K.A.P.) related to this disease and its treatments have been studied according to cultural group and geographical settlement. Within the Wayãpi group, the evolution of the knowledge of phytoremedies over the last 20 years has been characterised by literature-based comparisons. Materials and methods: A total of 144 questionnaires were administered in all the villages of the upper Oyapock and Camopi basins. Correspondence analyses were used for multivariate analysis. Plant species were identified at the Cayenne Herbarium (CAY). Results: The biomedical concept of leishmaniasis correlates well with the Teko and Wayãpi concepts of kalasapa and kalasapau. Although the vector of this disease was not correctly identified, the most commonly cited aetiology (74.5%) was vector-borne, and related epidemiological schemes correlate well with the one encountered in French Guiana. Theoretically and practically, health centres were the most commonly used resource for diagnostic in instances of leishmaniasis infection (65.9%), independently of the patient's cultural group, along with the use of pharmaceutical drugs (85.3%). Pharmaceuticals were commonly utilised despite the frequent (51.5%) use of phytotherapeutic remedies, alone or in combination with drugs. The most cited medicinal plant species for the treatment of leishmaniasis included Eleutherine bulbosa (Mill.) Urb. (Iridaceae, cited 14 times), Euterpe oleracea Mart. (Arecaceae, 9), Cecropia obtusa Trecul (Cecropiaceae, 8), Jatropha curcas L. (Euphorbiaceae, 7), Ceiba pentandra (L.) Gaertn. (Bombacaceae, 6) and Carica papaya L. (Caricaceae, 6). Multiple correspondence analyses demonstrated that the species used in leishmaniasis remedies are more prone to vary by the user's place of residence than by their cultural origin, which indicates that exchange of knowledge about leishmaniasis remedies has occurred across different cultural groups. Literature-based comparisons between the remedies for leishmaniasis used by the Wayãpi during the 1980s showed a striking evolution, both in terms of diversity of species and number of plants used. The large number of species shared with other Guianese groups argues for intercultural exchange and may explain the majority (57.1%) of the newly used species highlighted in our study. Conclusions: Leishmaniasis is a well-known disease in the studied area. Phytotherapeutic treatments are still in use, although they are not the main source of remedies, and should undergo pharmacological studies to evaluate their potential therapeutic value. © 2011 Elsevier Ireland Ltd. All rights reserved. |
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IRD, UMR152, F-31062 Toulouse Cedex 9, France |
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03788741 (Issn) |
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Export Date: 8 November 2011; Source: Scopus; Article in Press; Coden: Joetd; doi: 10.1016/j.jep.2011.07.044; Language of Original Document: English; Correspondence Address: Odonne, G.; CNRS-UMR Ecofog, Université des Antilles et de la Guyane, 97337 Cayenne Cedex, Franceemail: guillaume.odonne@gmail.com |
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EcoFoG @ webmaster @ |
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368 |
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Odonne, G.; Bourdy, G.; Beauchene, J.; Houel, E.; Stien, D.; Chevolot, L.; Deharo, E. |
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Title |
From Tonic-cups to Bitter-cups: Kwasi bita beker from Suriname Determination, past and present use of an ancient galenic artefact |
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Journal Article |
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Year |
2007 |
Publication |
Journal of Ethnopharmacology |
Abbreviated Journal |
J. Ethnopharmacol. |
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110 |
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2 |
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318-322 |
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Tonic-cup; Bitter-cup; Quassia amara; Suriname; traditional remedy |
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In the main markets of Paramaribo (Suriname), many stands offer what is locally called “Bitter-cups”, or “Kwasi bita beker”, small footed-cups, roughly carved from a whitish wood. The use of these cups is strictly medicinal and it seems to be restricted to Suriname, as they are not found in neighbouring countries (Guyana, French Guiana). The aim of this study was to identify the botanical origin of Bitter-cups still in use in the Saramaka traditional medicine (as information from field people was controversial), and document the ethnopharmacology of this original galenical artefact. Microscopic and high performance liquid chromatography (HPLC) analyses were carried out on Bitter-cup, and anatomical criteria (marginal parenchyma band, size of intervessel and vessel-ray pits, rays width and rays composition, vessels clustering, frequency and size of parenchyma pits) together with HPLC profiles of the macerates showed that the wood cup was similar to Quassia amara L. (Simaroubaceae) wood. Ethnopharmacological investigation indicates that the use of these cups is simply due to the pharmacological properties attributed to “bitters”, and is strongly linked to tradition and cultural attitudes. This study also emphasizes the long lasting use of these cups, now restricted to Suriname only, with almost no variation over one century. (c) 2006 Elsevier Ireland Ltd. All rights reserved. |
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Univ Toulouse 3, Ctr IRD, UMR 152, F-97323 Cayenne, France, Email: genevieve.bourdy@ird.fr |
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ELSEVIER IRELAND LTD |
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0378-8741 |
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ISI:000245486900012 |
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EcoFoG @ eric.marcon @ |
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166 |
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Odonne, G.; Bourdy, G.; Castillo, D.; Estevez, Y.; Lancha-Tangoa, A.; Alban-Castillo, J.; Deharo, E.; Rojas, R.; Stien, D.; Sauvain, M. |
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Ta'ta', Huayani: Perception of leishmaniasis and evaluation of medicinal plants used by the Chayahuita in Peru. Part II |
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Journal Article |
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2009 |
Publication |
Journal of Ethnopharmacology |
Abbreviated Journal |
J. Ethnopharmacol. |
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Volume |
126 |
Issue |
1 |
Pages |
149-158 |
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Leishmaniasis; Medicinal plants; Traditional medicine; Chayahuita; Peru |
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Abstract |
Aim of the study v: A knowledge attitude and practice study centred on leishmaniasis and its treatment was performed among the Chayahuita, in Amazonian Peruvian ethnic group living in ail endemic area. This study documents traditional Chayahuita plant's use and disease concepts. Also, activity of some medicinal Plants Used by the Chayahuita is highlighted and discussed. Materials and methods: Ninety-three Chayahuita people were interviewed, following a semi-structured questionnaire focussed oil disease knowledge and perception, personal attitude and healing practices. Simultaneously, a collection of plants was performed in different ecotopes, in order to make ail extensive inventory of the pharmacopoeia. Results: For the Chayahuita, cutaneous (CL) and muco-cutaneous leishmaniasis (MCL) are considered as diseases of their own, with specific names, aetiologics, mode of transmission. Regarding CL, Chayahuita people consider that the humid characteristic of the Skill ulcer is a discriminative fact orienting the diagnostic for Ta'ta' (leishmaniasis). Forty-six different species were designated useful against LC and /or MCL (29 species by means of the questionnaire and 27 species when collecting in different ecotopes). Thirty-seven extracts corresponding to 31 Species used medicinally were screened in vitro against Leishmania amazonensis axenic amastigotes, assessing their viability by the reduction Of tetrazolium salt (MTT). Six species displayed a good activity (10 μg/ml < IC50 < 20 μg/ml): all undetermined hemi-epiphytic Clusiaceae. Cybianthus anthuriophyllus Pipoly (Myrsinaceae), two Piper, Piper sanguineispicum Trel., and Piper loretoanum Trel. (Piperaceae), Desmodium axillare Sw. DC. (Fabaceae), and Clibadium sylvestre (Aubl.) Baill (Asteraceae). Conclusion: Perception of leishmaniasis, attitude. treatments and diet prohibitions still largely reflects traditional Chayahuita cosmovision, even if some tentative of bio-medical re-interpretation is arising. (C) 2009 Elsevier Ireland Ltd. All rights reserved. |
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[Odonne, G.; Bourdy, G.; Estevez, Y.; Deharo, E.; Sauvain, M.] Univ Toulouse, UPS, UMR 152, Lab Pharmacochim Subst Nat & Pharmacophores Redox, F-31062 Toulouse 9, France, Email: Genevieve.bourdy@ird.fr |
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ELSEVIER IRELAND LTD |
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0378-8741 |
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ISI:000271790800020 |
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EcoFoG @ eric.marcon @ |
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95 |
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