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Author (up) Bertani, S.; Houel, E.; Jullian, V.; Bourdy, G.; Valentin, A.; Stien, D.; Deharo, E. url  openurl
  Title New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae) Type Journal Article
  Year 2012 Publication Experimental Parasitology Abbreviated Journal Exp. Parasitol.  
  Volume 130 Issue 4 Pages 341-347  
  Keywords Antimalarial; Plasmodium; Quassia amara; Quassinoid; Simalikalactone d  
  Abstract Quassia amara L. (Simaroubaceae) is a species widely used as tonic and is claimed to be an efficient antimalarial all over the Northern part of the Amazon basin. Quassinoid compound Simalikalactone D (SkD) has been shown to be one of the molecules responsible for the antiplasmodial activity of a watery preparation made out of juvenile fresh leaves of this plant. Because of its strong antimalarial activity, we decided to have a further insight of SkD pharmacological properties, alone or in association with classical antimalarials. At concentrations of up to 200 μM, we showed herein that SkD did not exert any apoptotic or necrotic activities in vitro on lymphoblastic cells. However, an antiproliferative effect was evident at concentrations higher than 45. nM. SkD was inefficient at inhibiting heme biomineralization and the new permeability pathways induced by the parasite in the host erythrocyte membrane. With respect to Plasmodium falciparum erythrocytic stages, SkD was almost inactive on earlier and later parasite stages, but potently active at the 30th h of parasite cycle when DNA replicates in mature trophozoites. In vitro combination studies with conventional antimalarial drugs showed that SkD synergizes with atovaquone (ATO). The activity of ATO on the Plasmodium mitochondrial membrane potential was enhanced by SkD, which on its own had a poor effect on this cellular parameter. © 2012 Elsevier Inc.  
  Address UMR152 IRD-UPS, Institut de Recherche pour le Développement (IRD), Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 00144894 (Issn) ISBN Medium  
  Area Expedition Conference  
  Notes Export Date: 24 April 2012; Source: Scopus; Coden: Expaa; doi: 10.1016/j.exppara.2012.02.013; Language of Original Document: English; Correspondence Address: Deharo, E.; UMR152 IRD-UPS, Faculté de Pharmacie, 35 chemin des maraîchers, 31062 Toulouse cedex 9, France; email: Approved no  
  Call Number EcoFoG @ webmaster @ Serial 395  
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