TY  - JOUR
AU  - Houel, E.
AU  - Bertani, S.
AU  - Bourdy, G.
AU  - Deharo, E.
AU  - Jullian, V.
AU  - Valentin, A.
AU  - Chevalley, S.
AU  - Stien, D.
PY  - 2009//
TI  - Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity
T2  - J. Ethnopharmacol.
JO  - Journal of Ethnopharmacology
SP  - 114
EP  - 118
VL  - 126
IS  - 1
PB  - ELSEVIER IRELAND LTD
KW  - Quassia amara L.
KW  - Simaroubaceae
KW  - Leaf tea
KW  - Antimalarial activity
KW  - Cytotoxicity
KW  - Simalikalactone D
N2  - Aim of the study: Our objective was to assess whether it could be contemplated to recommend Quassia amara young leaf tea for treatment against malaria. and if yes. set up a standard protocol for preparing the herbal tea. Materials and methods: The leaf tea was extracted with methylene chloride and the organic extract was fractionated with HPLC. Pure compounds were characterized and their in vitro cytotoxicity and antiplasmodial activity was determined. Results and discussion: We discovered that antimalarial Quassia amara young leaf tea contains several quassinoids: simalikalactone D (SkD. 1), picrasin B (2). picrasin H (3), neoquassin (4), quassin (5), picrasin 1(6) and picrasin J (7). These last two compounds are new. In addition. our experiments demonstrate that both biological activity and cytotoxicity of the remedy may be attributed solely to the presence of SkD. Conclusion: In conclusion, this preparation Should not be recommended for treatment of malaria until a clinical Study in humans is performed with SkD. (C) 2009 Elsevier Ireland Ltd. All rights reserved
SN  - 0378-8741
N1  - ISI:000271790800015
ID  - Houel_etal2009
ER  -