TY  - JOUR
AU  - Cabanillas, B.J.
AU  - Le Lamer, A.C.
AU  - Castillo, D.
AU  - Arevalo, J.
AU  - Rojas, R.
AU  - Odonne, G.
AU  - Bourdy, G.
AU  - Moukarzel, B.
AU  - Sauvain, M.
AU  - Fabre, N.
PY  - 2010//
TI  - Caffeic Acid Esters and Lignans from Piper sanguineispicum
T2  - J. Nat. Prod.
JO  - Journal of Natural Products
SP  - 1884
EP  - 1890
VL  - 73
IS  - 11
PB  - AMER CHEMICAL SOC
N2  - Three new caffeic acid esters (1-3), four new lignans (4-7), and the known compounds (7'S)-parabenzlactone (8), dihydrocubebin (9), and justiflorinol (10) have been isolated from leaves of Piper sanguineispicum. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRCIMS, CD experiments, and chemical methods. Compounds 1-10 were assessed for their antileishmanial potential against axenic amastigote forms of Leishmania amazonensis. Caffeic acid esters 1 and 3 exhibited the best antileishmanial activity (IC50 2.0 and 1.8 μM, respectively) with moderate cytotoxicity on murine macrophages.
SN  - 0163-3864
N1  - ISI:000284559100024
ID  - Cabanillas_etal2010
ER  -