PT Journal
AU Cabanillas, B
   Le Lamer, A
   Castillo, D
   Arevalo, J
   Rojas, R
   Odonne, G
   Bourdy, G
   Moukarzel, B
   Sauvain, M
   Fabre, N
TI Caffeic Acid Esters and Lignans from Piper sanguineispicum
SO Journal of Natural Products
JI J. Nat. Prod.
PY 2010
BP 1884
EP 1890
VL 73
IS 11
AB Three new caffeic acid esters (1-3), four new lignans (4-7), and the known compounds (7'S)-parabenzlactone (8), dihydrocubebin (9), and justiflorinol (10) have been isolated from leaves of Piper sanguineispicum. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRCIMS, CD experiments, and chemical methods. Compounds 1-10 were assessed for their antileishmanial potential against axenic amastigote forms of Leishmania amazonensis. Caffeic acid esters 1 and 3 exhibited the best antileishmanial activity (IC50 2.0 and 1.8 μM, respectively) with moderate cytotoxicity on murine macrophages.
ER