PT Journal
AU Nirma, C
   Eparvier, V
   Stien, D
TI Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a nasutitermes sp. termite
SO Journal of Natural Products
JI J. Nat. Prod.
PY 2013
BP 988
EP 991
VL 76
IS 5
AB Defense mutualisms between social insects and microorganisms have been described in the literature. The present article describes the discovery of a Pseudallescheria boydii strain isolated from Nasutitermes sp. The microbial symbiont produces two antifungal metabolites: tyroscherin and N-methyltyroscherin, a compound not previously described in the literature. Methylation of tyroscherin has confirmed the structure of N-methyltyroscherin. Both compounds are effective antifungal agents with favorable selectivity indices for Candida albicans and Trichophyton rubrum. © 2013 The American Chemical Society and American Society of Pharmacognosy.
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