%0 Journal Article
%T Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a nasutitermes sp. termite
%A Nirma, C.
%A Eparvier, V.
%A Stien, D.
%J Journal of Natural Products
%D 2013
%V 76
%N 5
%@ 01633864 (Issn)
%F Nirma_etal2013
%O Export Date: 6 June 2013; Source: Scopus; Coden: Jnprd; :doi 10.1021/np4001703; Language of Original Document: English; Correspondence Address: Eparvier, V.; CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France; email: veronique.eparvier@icsn.cnrs-gif.fr
%O exported from refbase (http://php.ecofog.gf/refbase/show.php?record=491), last updated on Thu, 06 Jun 2013 08:16:45 -0300
%X Defense mutualisms between social insects and microorganisms have been described in the literature. The present article describes the discovery of a Pseudallescheria boydii strain isolated from Nasutitermes sp. The microbial symbiont produces two antifungal metabolites: tyroscherin and N-methyltyroscherin, a compound not previously described in the literature. Methylation of tyroscherin has confirmed the structure of N-methyltyroscherin. Both compounds are effective antifungal agents with favorable selectivity indices for Candida albicans and Trichophyton rubrum. © 2013 The American Chemical Society and American Society of Pharmacognosy.
%U http://www.scopus.com/inward/record.url?eid=2-s2.0-84878224354&partnerID=40&md5=3cdeb9ae06ce6645d6835533e1a64e29
%P 988-991