@Article{Nirma_etal2012,
author="Nirma, C.
and Rodrigues, A.M.S.
and Basset, C.
and Chevolot, L.
and Girod, R.
and Moretti, C.
and Stien, D.
and Dusfour, I.
and Eparvier, V.",
title="Larvicidal activity of isoflavonoids from Muellera frutescens extracts against Aedes aegypti",
journal="Natural Product Communications",
year="2012",
volume="7",
number="10",
pages="1319--1322",
optkeywords="Aedes aegypti",
optkeywords="French Guiana",
optkeywords="Insecticides",
optkeywords="Isoflavonoids",
optkeywords="Muellera frutescens",
abstract="The biological activity of extracts from the leaves, bark and roots of Muellera frutescens, an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides. The n-hexane extracts of bark, leaf, and root showed a strong toxic activity against Aedes aegypti mosquito larvae. Bioguided fractionation of the bark extract led to the isolation of seven isoflavonoids (12a-hydroxyelliptone, elliptone, (-)-variabilin, rotenone, rotenolone, tephrosin and deguelin). Rotenone and deguelin are responsible for the larvicidal activity of the plant. M. frutescens leaves contain up to 0.6\%, w/w, deguelin. These results justify the traditional ichtyotoxic use of M. frutescens. The leaves contain a relatively high proportion of deguelin and, therefore, can be considered as a renewable source of this environmentally friendly insecticidal isoflavonoid.",
optnote="Export Date: 6 December 2012; Source: Scopus",
optnote="exported from refbase (http://php.ecofog.gf/refbase/show.php?record=448), last updated on Tue, 17 Jan 2017 18:34:52 -0300",
doi="10.1021/np4001703"
}