TY  - JOUR
AU  - Cachet, N.
AU  - Ho-A-Kwie, F.
AU  - Rivaud, M.
AU  - Houel, E.
AU  - Deharo, E.
AU  - Bourdy, G.
AU  - Jullian, V.
PY  - 2012//
TI  - Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae)
T2  - Phytochem. Lett.
JO  - Phytochemistry Letters
SP  - 162
EP  - 164
VL  - 5
IS  - 1
KW  - Malaria
KW  - P. falciparum
KW  - Quassia amara
KW  - Quassinoids
KW  - Simaroubaceae
N2  - A new quassinoid Picrasin K 1 was isolated from a decoction made of Quassia amara leaves, traditionally used in French Guyana to treat malaria. The structure and relative stereochemistry of 1 was determined through extensive NMR analysis. Picrasin K showed a low activity against Plasmodium falciparum in vitro (IC 50 = 8 μM), and a similar low activity on human cancerous cells line (IC 50 = 7 μM on MCF-7 cells line). © 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
SN  - 18743900 (Issn)
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-84856701045&partnerID=40&md5=ec6ef03134af95b40652427eb15acba9
N1  - Export Date: 8 March 2012; Source: Scopus; doi: 10.1016/j.phytol.2011.12.001; Language of Original Document: English; Correspondence Address: Jullian, V.; UMR-152 Pharma-Dev, IRD, Université Paul Sabatier Toulouse 3, 31062 Toulouse, France; email: jullian@cict.fr
ID  - Cachet_etal2012
ER  -