PT Journal
AU Cachet, N
   Ho-A-Kwie, F
   Rivaud, M
   Houel, E
   Deharo, E
   Bourdy, G
   Jullian, V
TI Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae)
SO Phytochemistry Letters
JI Phytochem. Lett.
PY 2012
BP 162
EP 164
VL 5
IS 1
DE Malaria; P. falciparum; Quassia amara; Quassinoids; Simaroubaceae
AB A new quassinoid Picrasin K 1 was isolated from a decoction made of Quassia amara leaves, traditionally used in French Guyana to treat malaria. The structure and relative stereochemistry of 1 was determined through extensive NMR analysis. Picrasin K showed a low activity against Plasmodium falciparum in vitro (IC 50 = 8 μM), and a similar low activity on human cancerous cells line (IC 50 = 7 μM on MCF-7 cells line). © 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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