%0 Journal Article
%T Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae)
%A Cachet, N.
%A Ho-A-Kwie, F.
%A Rivaud, M.
%A Houel, E.
%A Deharo, E.
%A Bourdy, G.
%A Jullian, V.
%J Phytochemistry Letters
%D 2012
%V 5
%N 1
%@ 18743900 (Issn)
%F Cachet_etal2012
%O Export Date: 8 March 2012; Source: Scopus; doi: 10.1016/j.phytol.2011.12.001; Language of Original Document: English; Correspondence Address: Jullian, V.; UMR-152 Pharma-Dev, IRD, Université Paul Sabatier Toulouse 3, 31062 Toulouse, France; email: jullian@cict.fr
%O exported from refbase (http://php.ecofog.gf/refbase/show.php?record=382), last updated on Mon, 21 Jan 2013 11:39:48 -0300
%X A new quassinoid Picrasin K 1 was isolated from a decoction made of Quassia amara leaves, traditionally used in French Guyana to treat malaria. The structure and relative stereochemistry of 1 was determined through extensive NMR analysis. Picrasin K showed a low activity against Plasmodium falciparum in vitro (IC 50 = 8 μM), and a similar low activity on human cancerous cells line (IC 50 = 7 μM on MCF-7 cells line). © 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
%K Malaria
%K P. falciparum
%K Quassia amara
%K Quassinoids
%K Simaroubaceae
%U http://www.scopus.com/inward/record.url?eid=2-s2.0-84856701045&partnerID=40&md5=ec6ef03134af95b40652427eb15acba9
%P 162-164