PT Journal
AU Basset, C
   Rodrigues, A
   Eparvier, V
   Silva, M
   Lopes, N
   Sabatier, D
   Fonty, E
   Espindola, L
   Stien, D
TI Secondary metabolites from Spirotropis longifolia (DC) Baill and their antifungal activity against human pathogenic fungi
SO Phytochemistry
JI Phytochemistry
PY 2012
BP 166
EP 172
VL 74
DE Antifungal; Cytotoxic; Leguminosae; Monodominant species; Prenylated pterocarpans; Spirotropis longifolia
AB A phytochemical study of the ethyl acetate extract of the roots and adventitious roots of Spirotropis longifolia, a monodominant tree species of the Guianan rainforest, has allowed the isolation of three compounds: 2-hydroxy-8,9-methylenedioxy-2′,2′-dimethylpyrano-[5′, 6′:4,3]-6a-prenyl-[6aS,11aS]-pterocarpan (spirotropin A), 2-hydroxy-8,9-methylenedioxy-2′,2′-dimethyl-3′, 4′-dihydropyrano-[5′,6′:4,3]-6a-prenyl-[6aS,11aS]-pterocarpan (spirotropin B), and 5,7-dihydroxy-6,8-diprenyl-2,2-dimethylpyrano[5,6: 3′,4′]-isoflavone (spirotropone). In addition, 10 known compounds, trans-oxyresveratrol, trans-resveratrol, piceatannol, daidzein, genistein, isoprunetin, lupeol, latifolol, gnetin D and gnetin E, were also isolated. These compounds were evaluated for their antifungal activity and their cytotoxicity, and their structures were established by 1D and 2D NMR, HRMS, CD and optical rotation measurements. © 2011 Elsevier Ltd. All rights reserved.
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