TY  - JOUR
AU  - Marti, G.
AU  - Eparvier, V.
AU  - Moretti, C.
AU  - Prado, S.
AU  - Grellier, P.
AU  - Hue, N.
AU  - Thoison, O.
AU  - Delpech, B.
AU  - Gueritte, F.
AU  - Litaudon, M.
PY  - 2010//
TI  - Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae)
T2  - Phytochemistry
JO  - Phytochemistry
SP  - 964
EP  - 974
VL  - 71
IS  - 8-9
PB  - PERGAMON-ELSEVIER SCIENCE LTD
KW  - Symphonia globulifera
KW  - Clusiaceae
KW  - Benzophenone
KW  - Symphonone
KW  - Antiplasmodial
KW  - LC/ESI-MS
N2  - In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The ethyl acetate extract obtained from the root barks of Symphonia globulifera exhibited a strong antiplasmodial activity (97% at 10 μg/ml). The phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol (PPAPs) compounds and two oxidized derivatives. All compounds showed antiplasmodial activity with IC(50)s ranged from 2.1 to 10.1 μM. A LC/ESI-MSn study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation. (C) 2010 Elsevier Ltd. All rights reserved.
SN  - 0031-9422
N1  - ISI:000279077400016
ID  - Marti_etal2010
ER  -