@Article{Marti_etal2010,
author="Marti, G.
and Eparvier, V.
and Moretti, C.
and Prado, S.
and Grellier, P.
and Hue, N.
and Thoison, O.
and Delpech, B.
and Gueritte, F.
and Litaudon, M.",
title="Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae)",
journal="Phytochemistry",
year="2010",
publisher="PERGAMON-ELSEVIER SCIENCE LTD",
volume="71",
number="8-9",
pages="964--974",
optkeywords="Symphonia globulifera",
optkeywords="Clusiaceae",
optkeywords="Benzophenone",
optkeywords="Symphonone",
optkeywords="Antiplasmodial",
optkeywords="LC/ESI-MS",
abstract="In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The ethyl acetate extract obtained from the root barks of Symphonia globulifera exhibited a strong antiplasmodial activity (97\% at 10 $\mu$g/ml). The phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol (PPAPs) compounds and two oxidized derivatives. All compounds showed antiplasmodial activity with IC(50)s ranged from 2.1 to 10.1 $\mu$M. A LC/ESI-MSn study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation. (C) 2010 Elsevier Ltd. All rights reserved.",
optnote="ISI:000279077400016",
optnote="exported from refbase (http://php.ecofog.gf/refbase/show.php?record=284), last updated on Wed, 04 May 2011 12:17:30 -0300",
issn="0031-9422"
}