PT Journal
AU Marti, G
   Eparvier, V
   Litaudon, M
   Grellier, P
   Gueritte, F
TI A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds
SO Molecules
JI Molecules
PY 2010
BP 7106
EP 7114
VL 15
IS 10
DE Rheedia acuminata; Clusiaceae; xanthones; antiplasmodial activity; cytotoxicity
AB Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.
ER