TY  - JOUR
AU  - Bertani, S.
AU  - Houel, E.
AU  - Stien, D.
AU  - Chevolot, L.
AU  - Jullian, V.
AU  - Garavito, G.
AU  - Bourdy, G.
AU  - Deharo, E.
PY  - 2006//
TI  - Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)
T2  - J. Ethnopharmacol.
JO  - Journal of Ethnopharmacology
SP  - 155
EP  - 157
VL  - 108
IS  - 1
PB  - ELSEVIER IRELAND LTD
KW  - antimalarial
KW  - Quassia amara
KW  - quassinoids
KW  - simalikalactone D
KW  - traditional medicine
N2  - French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10 nM against FeB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
SN  - 0378-8741
N1  - ISI:000241573000023
ID  - Bertani_etal2006
ER  -