PT Journal
AU Bertani, S
   Houel, E
   Stien, D
   Chevolot, L
   Jullian, V
   Garavito, G
   Bourdy, G
   Deharo, E
TI Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)
SO Journal of Ethnopharmacology
JI J. Ethnopharmacol.
PY 2006
BP 155
EP 157
VL 108
IS 1
DE antimalarial; Quassia amara; quassinoids; simalikalactone D; traditional medicine
AB French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10 nM against FeB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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