%0 Journal Article
%T Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)
%A Bertani, S.
%A Houel, E.
%A Stien, D.
%A Chevolot, L.
%A Jullian, V.
%A Garavito, G.
%A Bourdy, G.
%A Deharo, E.
%J Journal of Ethnopharmacology
%D 2006
%V 108
%N 1
%I ELSEVIER IRELAND LTD
%@ 0378-8741
%F Bertani_etal2006
%O ISI:000241573000023
%O exported from refbase (http://php.ecofog.gf/refbase/show.php?record=173), last updated on Wed, 04 May 2011 09:55:36 -0300
%X French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10 nM against FeB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
%K antimalarial
%K Quassia amara
%K quassinoids
%K simalikalactone D
%K traditional medicine
%P 155-157