@Article{Bertani_etal2006,
author="Bertani, S.
and Houel, E.
and Stien, D.
and Chevolot, L.
and Jullian, V.
and Garavito, G.
and Bourdy, G.
and Deharo, E.",
title="Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)",
journal="Journal of Ethnopharmacology",
year="2006",
publisher="ELSEVIER IRELAND LTD",
volume="108",
number="1",
pages="155--157",
optkeywords="antimalarial",
optkeywords="Quassia amara",
optkeywords="quassinoids",
optkeywords="simalikalactone D",
optkeywords="traditional medicine",
abstract="French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10 nM against FeB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50\% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea. (c) 2006 Elsevier Ireland Ltd. All rights reserved.",
optnote="ISI:000241573000023",
optnote="exported from refbase (http://php.ecofog.gf/refbase/show.php?record=173), last updated on Wed, 04 May 2011 09:55:36 -0300",
issn="0378-8741"
}