TY  - JOUR
AU  - Nirma, C.
AU  - Rodrigues, A.M.S.
AU  - Basset, C.
AU  - Chevolot, L.
AU  - Girod, R.
AU  - Moretti, C.
AU  - Stien, D.
AU  - Dusfour, I.
AU  - Eparvier, V.
PY  - 2012//
TI  - Larvicidal activity of isoflavonoids from Muellera frutescens extracts against Aedes aegypti
JO  - Natural Product Communications
SP  - 1319
EP  - 1322
VL  - 7
IS  - 10
KW  - Aedes aegypti
KW  - French Guiana
KW  - Insecticides
KW  - Isoflavonoids
KW  - Muellera frutescens
N2  - The biological activity of extracts from the leaves, bark and roots of Muellera frutescens, an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides. The n-hexane extracts of bark, leaf, and root showed a strong toxic activity against Aedes aegypti mosquito larvae. Bioguided fractionation of the bark extract led to the isolation of seven isoflavonoids (12a-hydroxyelliptone, elliptone, (-)-variabilin, rotenone, rotenolone, tephrosin and deguelin). Rotenone and deguelin are responsible for the larvicidal activity of the plant. M. frutescens leaves contain up to 0.6%, w/w, deguelin. These results justify the traditional ichtyotoxic use of M. frutescens. The leaves contain a relatively high proportion of deguelin and, therefore, can be considered as a renewable source of this environmentally friendly insecticidal isoflavonoid.
UR  - http://dx.doi.org/10.1021/np4001703
N1  - Export Date: 6 December 2012; Source: Scopus
ID  - Nirma_etal2012
ER  -