%0 Journal Article
%T Larvicidal activity of isoflavonoids from Muellera frutescens extracts against Aedes aegypti
%A Nirma, C.
%A Rodrigues, A.M.S.
%A Basset, C.
%A Chevolot, L.
%A Girod, R.
%A Moretti, C.
%A Stien, D.
%A Dusfour, I.
%A Eparvier, V.
%J Natural Product Communications
%D 2012
%V 7
%N 10
%F Nirma_etal2012
%O Export Date: 6 December 2012; Source: Scopus
%O exported from refbase (http://php.ecofog.gf/refbase/show.php?record=448), last updated on Tue, 17 Jan 2017 18:34:52 -0300
%X The biological activity of extracts from the leaves, bark and roots of Muellera frutescens, an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides. The n-hexane extracts of bark, leaf, and root showed a strong toxic activity against Aedes aegypti mosquito larvae. Bioguided fractionation of the bark extract led to the isolation of seven isoflavonoids (12a-hydroxyelliptone, elliptone, (-)-variabilin, rotenone, rotenolone, tephrosin and deguelin). Rotenone and deguelin are responsible for the larvicidal activity of the plant. M. frutescens leaves contain up to 0.6%, w/w, deguelin. These results justify the traditional ichtyotoxic use of M. frutescens. The leaves contain a relatively high proportion of deguelin and, therefore, can be considered as a renewable source of this environmentally friendly insecticidal isoflavonoid.
%K Aedes aegypti
%K French Guiana
%K Insecticides
%K Isoflavonoids
%K Muellera frutescens
%U http://dx.doi.org/10.1021/np4001703
%P 1319-1322