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de Freitas, C., Silva, D., Kato, L., de Oliveira, C., Schuquel, I., da Silva, C., et al. (2012). New beta-carboline alkaloids from Galianthe ramosa (Rubiaceae). In Planta Medica (Vol. 78, 1182).
Abstract: Galianthe Griseb. (Rubiaceae, tribe Spermacoceae) is a genus comprising 50 endemic species in South America, its main center of diversity is located in central and southern Brazil. In our continuing chemical and biological investigations concerning Rubiaceae species from Cerrado, we report the isolation of new compounds 1 and 2, together with the known epi-catechin (3), ursolic and oleanolic acid. The alkaloid 2 inhibited the enzyme malato synthase from pathogenic fungus Paracoccidioides brasiliensis wich is considered an important target since it is not found in human.
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