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| Author | Rodrigues, A.; Theodoro, P.; Basset, C.; Espindola, L.; Stien, D. | ||||
| Title | Bio-inspiration in the discovery of active natural products: an example with the search of antifungal agents inspired from long-lasting woods | Type | Conference Article | ||
| Year | 2010 | Publication | Planta Medica | Abbreviated Journal | Planta Med. |
| Volume | 76 | Issue | 12 | Pages | 1293 |
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| Abstract | Plant natural products have been perfected through evolution with respect to their specific biological roles (defense, elicitor, and so on) and are, therefore, an excellent starting point in the search for new biologically active chemicals. Hence, despite the progressive abandonment of the exploration of naturally sourced bioactive substances by the pharmaceutical industry, more than half of the drugs approved in the United States between 2005 and 2007 are natural products or natural product-derived drugs, five of which constituted the first members of new drug classes [1]. Clearly, chemical research into natural substances still has an important role to play in improving quality of life, and can play an important role by inventing innovative strategies to discover new bioactive compounds [1,2].
In the present work, we demonstrated that a bio-inspired approach for the identification of novel bioactive natural products represents a promising biotechnological tool for the development of new drugs. We have studied how natural defenses within decay-resistant wood can generate a large number of positive hits in the search for antimycotic agents. In addition, it was found from bioguided fractionation that ethyl acetate extracts of Sextonia rubra wood contain a relatively large proportion of antifungal metabolites rubrenolide (1) and rubrynolide (2), 1 being slightly more active than 2. The therapeutic potential of the above compounds will be discussed through the evaluation of their antifungal activities against 16 pathogenic fungi strains and their cytotoxicities towards KB cells. |
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| Area | Expedition | Conference | 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 | ||
| Notes | Approved | no | |||
| Call Number | EcoFoG @ webmaster @ | Serial | 181 | ||
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| Author | Royer, M.; Herbette, G.; Eparvier, V.; Beauchêne, J.; Thibaut, B.; Stien, D. | ||||
| Title | Secondary metabolites of Bagassa guianensis Aubl. wood, a contribution to the understanding of the natural durability and to the chemotaxonomy of the Moraceae family with an unexplored genus | Type | Conference Article | ||
| Year | 2010 | Publication | Planta Medica | Abbreviated Journal | Planta Med. |
| Volume | 76 | Issue | 12 | Pages | 1375 |
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| Abstract | In effort to explain wood durability of Moraceae plants family, a phytochemical study was undertaken on Bagassa guianensis. The phytochemical investigation of the ethyl acetate extract obtained from the heartwood led to the isolation of 18 secondary metabolites, including 6 moracins [the new 6-O-methyl-moracin M (3), 6-O-methyl -moracin N (4) and moracin Z (5); the known moracin M (1), moracin N (2) and moracin P (6)], 8 phenolic derivatives [the new (-)-epialboctalol (12), arachidin 4 (10) and the known alboctalol (11), trans-resveratrol (7), arachidin 2 (9), trans-oxyresveratrol (8) and artogomezianol (13)], the 3 known flavonoids steppogenin (14), katuranin (15), dihydromorin (16), the β-sitosterol (17) and the resorcinol (18). Comparison with literature data indicates that stilbenoids are presumably responsible for the natural resistance of the wood against fungi degradation. In addition, chemical composition points out that B. guianensis is closely related to Morus sp. in the phylogeny and should be placed within the Moreae s. s. tribe in the Moraceae family, accordingly to the latest Weiblen genoma-based classifications [1,2]. | ||||
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| Area | Expedition | Conference | 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 | ||
| Notes | Approved | no | |||
| Call Number | EcoFoG @ webmaster @ | Serial | 182 | ||
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| Author | Basset, C.; Stien, D.; Espindola, S.L. | ||||
| Title | Research of antifungal compounds from the Amazonian biomass by a bio-inspired approach | Type | Conference Article | ||
| Year | 2010 | Publication | Planta Medica | Abbreviated Journal | Planta Med. |
| Volume | 76 | Issue | 12 | Pages | 1172 |
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| Abstract | Our research aims at understanding the chemical resistance mechanisms of durable woods against fungi. Our ultimate goal is to isolate and identify antifungal compounds from these woods that could be used for the treatment of human fungal diseases. We therefore screened highly durable Amazonian wood selected from technical databases [1] and demonstrated that bioactive secondary metabolites responsible of the natural durability of the woods [2] can also be used to treat mycoses. This screening has given a very high ... | ||||
| Address | Basset, C.] UAG, UMR ECOFOG, Cayenne 97337, French Guiana | ||||
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| ISSN | 0032-0943 | ISBN | Medium | ||
| Area | Expedition | Conference | 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 | ||
| Notes | ISI:000282066500035 | Approved | no | ||
| Call Number | EcoFoG @ webmaster @ | Serial | 183 | ||
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| Author | Marcon, Eric; Puech, Florence | ||||
| Title | La mesure en économie internationale, Quelques considérations méthodologiques. | Type | Book Chapter | ||
| Year | 2012 | Publication | Développements récents en économie et finances internationales | Abbreviated Journal | |
| Volume | Issue | Pages | 15-27 | ||
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| Publisher | Armand Colin | Place of Publication | Paris | Editor | Abdelmalki, Lahsen; Allegret, Jean-Pierre ; Puech, Florence ; Sadni Jallab, Mustapha ; Silem, Ahmed |
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| Series Editor | Series Title | Collection Recherches | Abbreviated Series Title | ||
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| Notes | Approved | no | |||
| Call Number | EcoFoG @ webmaster @ | Serial | 184 | ||
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| Author | Plomion, C.; Scotti, I.; Delzon, S.; Gion, J.-M. | ||||
| Title | Adaptation of forest trees to climate change | Type | Conference Article | ||
| Year | 2011 | Publication | BMC Proceedings: IUFRO Tree Biotechnology Conference 2011: From Genomes to Integration and Delivery | Abbreviated Journal | BMC Proceedings |
| Volume | 5 | Issue | Pages | I13 | |
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| ISSN | 1753-6561 | ISBN | Medium | ||
| Area | Expedition | Conference | IUFRO Tree Biotechnology Conference 2011: From Genomes to Integration and Delivery. Arraial d’Ajuda, Bahia, Brazil. 26 June - 2 July 2011 | ||
| Notes | Approved | no | |||
| Call Number | EcoFoG @ webmaster @ 1238 | Serial | 185 | ||
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| Author | Djenontin, S.T.; Amusant, N.; Ducrot, P.H.; Sohounhloue, D.C.K.; Pioch, D. | ||||
| Title | First report on the termiticidal activity of extracts of Annona squamosa (Annonaceae) seeds and on its active constituent squamocins | Type | Conference Article | ||
| Year | 2012 | Publication | 2012 IUFRO Conference proceedings | Abbreviated Journal | |
| Volume | Division 5 Forest products | Issue | Pages | 138-139 | |
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| Abstract | Termites inflict severe damage on wood and impede usage of several forest species. The biological metabolites could potentially replace synthetic termiticidal products which are becoming more restricted to use. Annona squamosa is well known for its edible fruits – tropical custard apple. Annonaceous tetrahydrofuran acetogenins have attracted much interest due to their broad range of biological activities, and seeds containing them are reported to show insecticidal and abortifacient properties.
Under the course our exploratory investigation of non food valuable products from less known forest species (here from Benin), the fractions obtained from defatted cake of Annona squamosa seeds with solvents covering a broad range of polarity, revealed a significant termiticidal activity, when applied at 5 – 10 mg/cm² (non-polar solvent) and 1.2 – 5 mg/cm² (case of a more polar solvent). Based on the result (0: no attack) from the standard procedure EN 118, these extracts could be used for preserving wood under class of use number 1. A derivatization step with Kedde reagents A and B, elemental analysis C,H,O, HPLC/MS and proton NMR showed the presence of squamocin type acetogenins (MW 594 and 622 g/mole: C35H62O7 and C37H66O7) as main components of the most active fraction (100% mortality within 7 days for a sample applied at 2 mg/cm²). Additional work will be undertaken to confirm the structure of most active compounds in the extracts, and to check whether some Annona squamosa seed extracts (non timber products of sustainable management of native forest) could show even higher activity to protect wood under more adverse conditions and be alternative active natural products to synthetic compounds. |
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| Publisher | Place of Publication | Lisbonne, Portugal | Editor | ||
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| Area | Expedition | Conference | 8-13 juillet 2012 | ||
| Notes | Approved | no | |||
| Call Number | EcoFoG @ webmaster @ | Serial | 186 | ||
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| Author | Molto, Quentin | ||||
| Title | Estimation de biomasse en forêt tropicale humide – Propagation des incertitudes dans la modélisation de la distribution spatiale de la biomasse en Guyane française; | Type | Thesis | ||
| Year | 2012 | Publication | Abbreviated Journal | ||
| Volume | Issue | Pages | 184 | ||
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| Publisher | Université des Antilles et de la Guyane | Place of Publication | Cayenne - Guyane française | Editor | |
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| Series Editor | Hérault, B. | Series Title | Abbreviated Series Title | ||
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| Notes | Approved | no | |||
| Call Number | EcoFoG @ carole.legrand @ | Serial | 195 | ||
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| Author | Thibaut, B.; Beauchêne, J. | ||||
| Title | Links between wood machining phenomena and wood mechanical properties: The case of 0°/90° orthogonal cutting of green wood | Type | Conference Article | ||
| Year | 2004 | Publication | Proceedings of the 2nd International Symposium on Wood Machining | Abbreviated Journal | |
| Volume | Issue | Pages | 149-160 | ||
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| Publisher | Place of Publication | Vienna | Editor | ||
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| Notes | Approved | no | |||
| Call Number | EcoFoG @ webmaster @ 1239 | Serial | 188 | ||
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| Author | Niamké, F.; Kokutse, A.D.; Kadio, A.A.; Lemenager, N.; Baudasse, C.; Nourissier-Mountou, S.; Adima, A.A.; Amusant, N.; Chaix G. | ||||
| Title | Nirs Tools for Prediction of Main Extractives Compounds of Teak (Tectona grandis L.) Heartwood | Type | Conference Article | ||
| Year | 2012 | Publication | 2012 IUFRO Conference proceedings | Abbreviated Journal | |
| Volume | Division 5 Forest products | Issue | Pages | ||
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| Abstract | Biochemical and physiological process which occurred during heartwood formation have consequences on wood properties such as colour, natural durability and some mechanical properties. However, it is very time-consuming to take measurements of extractives contents. Teak has been reported to contain 1-hydroxy-2-methyl-anthraquinone, 2-hydroxy-methyl-anthraquinone, 2-methyl-anthraquinone, lapachol, 1,4-naphthoquinone for the main compounds.
In teak, natural durability is ascribed to extractives. Consequently, it’s possible to estimate natural durability by measurement of extractives indirectly. For the purposes of selection for the production of improved varieties, the number of samples to be measured rapidly exceeds the capacity of a traditional laboratory. Near-infrared spectroscopy approach, based on spectral data and reference data, is a tool enabling many of the chemical properties of wood to be predicted and the number of laboratory measurements to be reduced exponentially. The issue here is a question of checking the effectiveness of NIRS tool to build models and predict the main extractive compounds of teak wood from Ivory Coast. We try to calibrate these chemical properties with Nirs spectral information measured on grounded wood. The results show the possible use of NIRS to predict total phenol content and some main extractive compounds of teak heartwood as tectoquinone, 2-hydroxymethylanthraquinone, … Consequently, after verification on other sets of teak samples, which may or may not be included in the prediction model, NIRS can be used to predict extractive compounds accurately for a large number of samples, making it possible to estimate natural durability indirectly and to include these characteristics in the selection criteria for classifying wood and high throughput phenotyping. |
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| Publisher | Place of Publication | Lisbonne, Portugal | Editor | ||
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| Area | Expedition | Conference | 8-13 juillet 2012 | ||
| Notes | Approved | no | |||
| Call Number | EcoFoG @ webmaster @ | Serial | 196 | ||
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| Author | Salvin, Paule ; Briswalter, Marion | ||||
| Title | De la lumière grâce à la mangrove | Type | Journal Article | ||
| Year | 2013 | Publication | Une Saison en Guyane | Abbreviated Journal | |
| Volume | Issue | 10 | Pages | 4 | |
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| Publisher | Atelier Aymara | Place of Publication | Cayenne - Guyane française | Editor | |
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| ISSN | 1966-6446 | ISBN | Medium | ||
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| Notes | Approved | no | |||
| Call Number | EcoFoG @ carole.legrand @ | Serial | 199 | ||
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