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Dejean, Alain |
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Title |
Ant-Plant Interactions: Impacts of Humans on Terrestrial Ecosystems edited by Paulo S. Oliveira and Suzanne Koptur |
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2018 |
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The Quarterly Review Of Biology |
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93 |
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2 |
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138-139 |
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Revue de l'ouvrage : Edited by Paulo S. Oliveira and Suzanne Koptur.
Cambridge and New York: Cambridge University Press.
$84.99. xix + 431 p. + 8 pl.; ill.; index. ISBN: 978-
1-107-15975-4. 2017. |
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EcoFoG @ webmaster @ |
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316 |
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Boulogne, Isabelle ; Amusant, Nadine ; Constantino, Réginaldo ; Falkowski, Michaël ; Rodrigues, Alice M.S ; Houël, Emeline |
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From the understanding of biological strategies to sustainable pest management: the case of Nasutitermes corniger |
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2018 |
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IGR/WP |
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18-10907 |
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23 |
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EcoFoG @ carole.legrand @ |
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320 |
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Davy, Damien ; Tritsch, Isabelle ; Grenand, Pierre |
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Title |
Construction et restructuration territoriale chez les Wayãpi et Teko de la commune de Camopi, Guyane française |
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2012 |
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Confins |
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16 |
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1-25 |
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EcoFoG @ carole.legrand @ |
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167 |
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Stien, D. ; Rodrigues, A.M.S. ; Makerri, C. ; Odonne, G. ; Eparvier, V. |
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Title |
Experimental design optimization of antimicrobial mixtures of active VOCs |
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Journal Article |
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2014 |
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Planta Medica |
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80 |
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16 |
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P1M3 |
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In this beginning of the 21st century, a child dies from malaria every minute in Sub-Saharan Africa and tuberculosis kills every 20 seconds [1]. Also, the hidden burden of chronic viral infections such as HIV and hepatitis B and C is sobering, affecting at least 1 in 20 people globally. In fact, many authors believe that humanity is on the verge of a post-antibiotic era [2]. We believe that something different has to be brought into the scientific debate around anti-infective agents. Our opinion is that natural synergistic mixtures, which have been protecting plants for ages, can inspire the discovery of synergistic pharmaceutical preparations. As a first model approach, a set of 66 essential oils has been analysed by GC-MS and tested (Minimal Inhibitory Concentration, MIC) against pathogenic yeasts Candida albicans and C. parapsilosis. A comparative holistic analysis of the dataset allowed us to identify 6 candidate anticandidal agents: Z-ligustilide, eugenol, eugenyl acetate, citral (mixture of geranial and neral), thymol, and β-citronellol. These compounds were combined following a full factorial experimental design approach in order to optimize the anticandidal selectivity index (SI = IC50 (MRC5 cells)/MIC) of the reconstituted mixtures. It was found that Z-ligustilide and eugenol are the two main factors that most contribute to the increase of the SI, while significantly positive interaction effect was recorded for these two compounds (Fig. 1). A positive interaction effect was also detected between citral and both Z-ligustilide and eugenol. These 3 plant defence compounds can therefore be used to construct anticandidal mixtures. |
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Thieme |
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Germany |
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EcoFoG @ carole.legrand @ |
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276 |
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Houel, E.; Bertani, S.; Bourdy, G.; Deharo, E.; Jullian, V.; Valentin, A.; Chevalley, S.; Stien, D. |
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Quassinoid constituents of Quassia amara L. (Simaroubaceae) leaf herbal tea. Impact on its antimalarial activity and cytotoxicity |
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Conference Article |
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2010 |
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Planta Medica |
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Planta Med. |
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76 |
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12 |
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1381-1382 |
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French Guiana records high malaria incidence rates. The traditional antimalarial remedy most widespread and still very much in use there is a tea made out from Quassia amara mature leaves. The antimalarial activity of this preparation was assessed [1] and in order to optimize the in vitro activity, different types of preparation have been realized and tested. The most active in vitro preparation is an infusion of fresh young leaves. It demonstrated a very good activity, in vitro as well as in vivo [2]. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10 nM against FcB1 Plasmodium falciparum chloroquine resistant strain in vitro [3]. Our next objective was to assess whether it could be contemplated to recommend this young leaves tea for treatment against malaria, since it seemed from literature precedent that SkD was also cytotoxic to a number of cellular lineages [4,5]. We then characterized and quantified the antiparasitic and cytotoxic activities of all the constituents. Several quassinoids were isolated and characterized in the tea: SkD, quassin, neoquassin, and picrasins B, H, I (new) and J (new), SkD being responsible of both antiplasmodial activity and cytotoxicity. In addition, in the context of an antimalarial treatment, it appeared that the dose necessary for obtaining a curative antimalarial effect is close to the toxic dose of an SkD analogue, bruceantin. Prior to emitting a definitive conclusion, a clinical study in humans similar to the one done with bruceantin [6] should be performed. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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EcoFoG @ webmaster @ |
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175 |
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Le Ven, J.; Eparvier, V.; Litaudon, M.; Gueritte, F. |
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Title |
Isolation of bioactive aporphinoid alkaloids in Oxandra asbecki (Annonaceae) |
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Conference Article |
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2010 |
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Planta Medica |
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Planta Med. |
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76 |
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12 |
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1287 |
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Since prehistoric times, humans beneficially used natural resources for their daylife needs. Plants are able to synthesize complex molecules and consequently have a unique chemical diversity. This is a source of inspiration for new drugs discovery. Dyrk1A kinase is a target used in research on Alzheimer's disease. Inhibition of this kinase is associated with treating symptoms of this disease [1,2]. In France, the annual number of new cases is 230 000. The prevalence is expected to double in industrialized countries and quadruple in developing countries in the coming decades. The development of a better diagnosis and treatment is essential. The Annonaceae is a large family of tropical plants that have been investigated intensively. There exist 38 species in Oxandra genus and Oxandra asbecki species in Venezuela and in primary forests of French Guiana. To the aim of discovering new bioactive plants from French Guiana, Oxandra asbecki was selected for phytochemical study because of its potent inhibition of DyrK1A kinase. Bioassay-directed fractionation of the ethyl acetate extract provided three bioactive alkaloids. We isolated three aporphinoid alkaloids and show for the first time an strong activity (with micromolar IC50) of Velutamin under two kinase: CDK1 and DyrK1A, and activity of Aristolactam AII on DyrK1A kinase. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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EcoFoG @ webmaster @ |
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177 |
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Nirma, C.; Rodrigues, A.; Basset, C.; Stien, D.; Eparvier, V. |
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Isoflavonoids with insecticide and larvicide activities from Muellera frutescens Standl |
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2010 |
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Planta Medica |
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Planta Med. |
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76 |
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12 |
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1197-1198 |
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Many plants of the Fabaceae family, are used as fish poisoning and insecticides [1,2]. The genus Muellera in this family is represented by only seven species of climbers and trees and is distributed over south and central America. In 1984, Geesink proposed to consider Muellera as Lonchocarpus synonymous [3]. The Lonchocarpus genera is well known in French Guiana because of its traditional utilization as a fish poisoning [4]. However, one study only reported ethnobotanical use of M. frutescens as an ichtyotoxic plant. Furthermore, no ethnopharmacological use or biological activity data was ever reported in the literature for this plant. Many chemical studies dealing with Lonchocarpus genera have been published [5,6,7]. Phytochemical investigation of barks, stems and rarely leaves described isolation of active isoflavonoids named rotenoids. This study aims at conducting a phytochemical survey of Muellera frutescens in order to evaluate whether or not Muellera is closely related to Lonchocarpus and eventually isolate new bioactive secondary metabolites. Three different extracts (hexane, ethyl acetate and methanol) of bark, roots and leaves were prepared and tested on various biological assays. We discovered insecticide and larvicide activities for all extracts, and none of them exhibited cytotoxicity on human cells. The bioguided fractionation of the most active extract (bark hexane extract) allowed us to isolate eight isoflavonoids, the structures of which were elucidated by spectroscopic methods. It was found that Muellera is indeed closely related to Lonchocarpus, therefore corroborating Geesink's proposal. |
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EcoFoG @ webmaster @ |
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178 |
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Odonne, G.; Stien, D.; Bourdy, G. |
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Two piptocarphols from Pseudoelephantopus spicatus (Asteraceae) may explain its traditional use against cutaneous leishmaniasis amongst the Chayahuita (Peruvian Amerindians) |
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2010 |
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Planta Medica |
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Planta Med. |
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76 |
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12 |
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1381 |
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Chayahuita Amerindians are dwelling in north-west Peruvian Amazon. As they live in an endemic area of cutaneous and muco-cutaneous leishmaniasis, they developed a rich pharmacopoeia against those well recognized diseases [1]. Pseudoelephantopus spicatus (B. Juss. ex Aubl.) Rohr ex Gleason (Asteraceae) is one of the most used Chayahuita remedies against cutaneous leishmaniasis. In the course of evaluating those remedies against in vitro axenic amastigotes of Leishmania amazonensis, P. spicatus extract was found to be very active. Bioguided fractionation led to 3 active compounds (8,13-O-diacetyl-piptocarphol (1), 8-O-acetyl-13-O-ethyl-piptocarphol (2) and ursolic acid. Although these compounds had already been identified in other plants of the Vernoniae tribe (P. spicatus tribe) [2,3], none of them had been isolated from this species. 1 and 2 were found to be more active than amphotericin B against the parasite (IC50 for 1: 0.08±0.04µg/mL, 2: 0.14±0.05mg/mL, and 0.38µg/mL for amphotericin B), explaining at least partially the use of P. spicatus based remedies. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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EcoFoG @ webmaster @ |
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179 |
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Rodrigues, A.; Espindola, S.; Beauchêne, J.; Stien, D. |
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Antifungal components from Amazonian long lasting heartwood |
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2010 |
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Planta Medica |
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Planta Med. |
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76 |
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12 |
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1172 |
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About thirty Andira species have been described in America and Africa but most of them are found in Amazonian Rain Forest [1]. In French Guiana and Brazil A. surinamensis, A. coriaceae and A. inermis timbers (all named Saint-Martin Rouge in French) are commercialized for residential construction because of their excellent resistance to decay in ground contact [2]. In this study A. surinamensis heartwood was extracted with solvent of increasing polarities and extracts were evaluated against wood rotting fungi and human pathogens. Ethyl acetate extract proved strongly antifungal, showing that durable heartwood is a promising source of active metabolites for wood treatment and human health applications. Bioguided chemical fractionation allowed us to isolate five isoflavonoids including biochanin A [3]. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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EcoFoG @ webmaster @ |
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180 |
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Rodrigues, A.; Theodoro, P.; Basset, C.; Espindola, L.; Stien, D. |
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Bio-inspiration in the discovery of active natural products: an example with the search of antifungal agents inspired from long-lasting woods |
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Conference Article |
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2010 |
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Planta Medica |
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Planta Med. |
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76 |
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12 |
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1293 |
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Plant natural products have been perfected through evolution with respect to their specific biological roles (defense, elicitor, and so on) and are, therefore, an excellent starting point in the search for new biologically active chemicals. Hence, despite the progressive abandonment of the exploration of naturally sourced bioactive substances by the pharmaceutical industry, more than half of the drugs approved in the United States between 2005 and 2007 are natural products or natural product-derived drugs, five of which constituted the first members of new drug classes [1]. Clearly, chemical research into natural substances still has an important role to play in improving quality of life, and can play an important role by inventing innovative strategies to discover new bioactive compounds [1,2].
In the present work, we demonstrated that a bio-inspired approach for the identification of novel bioactive natural products represents a promising biotechnological tool for the development of new drugs. We have studied how natural defenses within decay-resistant wood can generate a large number of positive hits in the search for antimycotic agents. In addition, it was found from bioguided fractionation that ethyl acetate extracts of Sextonia rubra wood contain a relatively large proportion of antifungal metabolites rubrenolide (1) and rubrynolide (2), 1 being slightly more active than 2. The therapeutic potential of the above compounds will be discussed through the evaluation of their antifungal activities against 16 pathogenic fungi strains and their cytotoxicities towards KB cells. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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EcoFoG @ webmaster @ |
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181 |
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