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Houel, E.; Rodrigues, A.; Jahn-Oyac, A.; Bessiere, J.; Eparvier, V.; Deharo, E.; Stien, D. |
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Title |
In vitro antifungal activity of Otacanthus azureus (Linden) Ronse essential oil alone and in combination with azoles |
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Conference Article |
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2012 |
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Planta Medica |
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78 |
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11 |
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1202 |
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We determined the chemical composition and investigated the antifungal activity of Otacanthus azureus (Linden) Ronse essential oil alone or combined with azoles antifungals against a range of human yeasts and dermatophytes. The oil was shown to be composed in majority of sesquiterpenes. Using broth microdilution techniques, it was found to exert interesting in vitro antifungal activities, more particularly against human dermatophytes, with minimum inhibitory concentrations as low as 4µg/ml against a clinical isolate of Trichophyton rubrum. The analysis of the combined effect of this oil with azoles highlighted a pronounced synergism between the oil and ketoconazole or itraconazole, against Candida albicans, C. parapsilosis and Trichophyton mentagrophytes, with fractional inhibitory concentration indices in the 0.1–0.5 range. Interestingly, the oil showed no cytotoxicity on VERO cells (ED50>100µg/ml). According to these results, O. azureus essential oil may be considered a promising natural product in the treatment of human mycoses, more particularly those originating from dermatophytic fungi. Also, it is likely to reduce the minimum effective dose of ketoconazole and itraconazole against Candida species, thus minimizing the side effects of these drugs, and the risk to develop resistances. |
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2012 International Congress on Natural Products Research, New York City, July 28- August 1, 2012 |
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EcoFoG @ webmaster @ |
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176 |
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Nirma, C.; Rodrigues, A.; Basset, C.; Stien, D.; Eparvier, V. |
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Title |
Isoflavonoids with insecticide and larvicide activities from Muellera frutescens Standl |
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Conference Article |
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2010 |
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Planta Medica |
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Planta Med. |
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76 |
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12 |
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1197-1198 |
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Many plants of the Fabaceae family, are used as fish poisoning and insecticides [1,2]. The genus Muellera in this family is represented by only seven species of climbers and trees and is distributed over south and central America. In 1984, Geesink proposed to consider Muellera as Lonchocarpus synonymous [3]. The Lonchocarpus genera is well known in French Guiana because of its traditional utilization as a fish poisoning [4]. However, one study only reported ethnobotanical use of M. frutescens as an ichtyotoxic plant. Furthermore, no ethnopharmacological use or biological activity data was ever reported in the literature for this plant. Many chemical studies dealing with Lonchocarpus genera have been published [5,6,7]. Phytochemical investigation of barks, stems and rarely leaves described isolation of active isoflavonoids named rotenoids. This study aims at conducting a phytochemical survey of Muellera frutescens in order to evaluate whether or not Muellera is closely related to Lonchocarpus and eventually isolate new bioactive secondary metabolites. Three different extracts (hexane, ethyl acetate and methanol) of bark, roots and leaves were prepared and tested on various biological assays. We discovered insecticide and larvicide activities for all extracts, and none of them exhibited cytotoxicity on human cells. The bioguided fractionation of the most active extract (bark hexane extract) allowed us to isolate eight isoflavonoids, the structures of which were elucidated by spectroscopic methods. It was found that Muellera is indeed closely related to Lonchocarpus, therefore corroborating Geesink's proposal. |
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178 |
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de Freitas, C.; Silva, D.; Kato, L.; de Oliveira, C.; Schuquel, I.; da Silva, C.; Santin, S.; Delprete, P.; Neto, B.; Soares, C.; Pereira, M. |
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New beta-carboline alkaloids from Galianthe ramosa (Rubiaceae) |
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Conference Article |
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2012 |
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Planta Medica |
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78 |
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11 |
Pages |
1182 |
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Galianthe Griseb. (Rubiaceae, tribe Spermacoceae) is a genus comprising 50 endemic species in South America, its main center of diversity is located in central and southern Brazil. In our continuing chemical and biological investigations concerning Rubiaceae species from Cerrado, we report the isolation of new compounds 1 and 2, together with the known epi-catechin (3), ursolic and oleanolic acid. The alkaloid 2 inhibited the enzyme malato synthase from pathogenic fungus Paracoccidioides brasiliensis wich is considered an important target since it is not found in human. |
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2012 International Congress on Natural Products Research, New York City, July 28- August 1, 2012 |
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EcoFoG @ webmaster @ |
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171 |
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Rodrigues, A.; Espindola, S.; Beauchêne, J.; Stien, D. |
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Title |
Antifungal components from Amazonian long lasting heartwood |
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Conference Article |
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Year |
2010 |
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Planta Medica |
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Planta Med. |
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76 |
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12 |
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1172 |
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About thirty Andira species have been described in America and Africa but most of them are found in Amazonian Rain Forest [1]. In French Guiana and Brazil A. surinamensis, A. coriaceae and A. inermis timbers (all named Saint-Martin Rouge in French) are commercialized for residential construction because of their excellent resistance to decay in ground contact [2]. In this study A. surinamensis heartwood was extracted with solvent of increasing polarities and extracts were evaluated against wood rotting fungi and human pathogens. Ethyl acetate extract proved strongly antifungal, showing that durable heartwood is a promising source of active metabolites for wood treatment and human health applications. Bioguided chemical fractionation allowed us to isolate five isoflavonoids including biochanin A [3]. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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EcoFoG @ webmaster @ |
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180 |
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Author |
Basset, C.; Stien, D.; Espindola, S.L. |
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Title |
Research of antifungal compounds from the Amazonian biomass by a bio-inspired approach |
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Conference Article |
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2010 |
Publication |
Planta Medica |
Abbreviated Journal |
Planta Med. |
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76 |
Issue |
12 |
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1172 |
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Our research aims at understanding the chemical resistance mechanisms of durable woods against fungi. Our ultimate goal is to isolate and identify antifungal compounds from these woods that could be used for the treatment of human fungal diseases. We therefore screened highly durable Amazonian wood selected from technical databases [1] and demonstrated that bioactive secondary metabolites responsible of the natural durability of the woods [2] can also be used to treat mycoses. This screening has given a very high ... |
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Basset, C.] UAG, UMR ECOFOG, Cayenne 97337, French Guiana |
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0032-0943 |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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ISI:000282066500035 |
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EcoFoG @ webmaster @ |
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183 |
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El Khil, M.; Houel, E.; Eparvier, V.; Stien, D. |
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Title |
Development of a statistical tool to predict anticandidal activity of essential oils |
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Conference Article |
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Year |
2012 |
Publication |
Planta Medica |
Abbreviated Journal |
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Volume |
78 |
Issue |
11 |
Pages |
1065 |
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There is a general agreement that natural volatile compounds of essentials oils from plants provide a great potential for discovery of new antimicrobial drugs such as anticandidal ones. In this work, 60 commercial essential oils were analysed by GC/MS and their inhibitory activity against the growth of three Candida strains was evaluated. We then conducted a chemometric analysis and proposed a tool to predict their capacity to inhibit the Candida sp. developpment. Raw data were pretreated and normalised using MZmine2.2 software. It was possible to identify some of the natural compounds with anticandidal properties using two statistical tools in XLstat7.5: hierarchical clustering analysis (HAC) and principal component analysis (PCA). We highlighted that essential oils containing limonene, 1,8-cineole, linalool and linalyl acetate were mostly inactive, whereas eugenol, thymol, carvacrol, geraniol, geranial and neral as major components of the oils seems to be linked to an interesting anticandidal activity. Linear regressions showed a high correlation between the concentration of these molecules and their antifungal activity. Exceptions to these general tendencies could be characteristic of synergistic or antagonistic interactions. |
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2012 International Congress on Natural Products Research, New York City, July 28- August 1, 2012 |
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EcoFoG @ webmaster @ |
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173 |
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Casella, T.; Eparvier, V.; de Mesquita, M.; Odonne, G.; Espindola, L.; Stien, D. |
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Title |
Bioactives products from leaves endophytes |
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Conference Article |
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2012 |
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Planta Medica |
Abbreviated Journal |
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78 |
Issue |
11 |
Pages |
1045-1046 |
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Leaves endophytes contribute to the natural defense of plant leaves, preventing both herbivory and invasion from superficial pathogens. It was therefore postulated that these microbes should produce antimicrobial and/or cytotoxic compounds. The isolated microorganisms belong to 14 different orders, the xylariales being the most represented (35 isolates, A). More than 20% of the extracts were considered active against at least one ... |
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2012 International Congress on Natural Products Research, New York City, July 28- August 1, 2012 |
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EcoFoG @ webmaster @ |
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170 |
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Salhi, L. ; Nait Rabah, O. ; Deyrat, C. ; Roos, C. |
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Numerical modeling of the screw pile behavior under tensile loading in cohesionless soil |
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2014 |
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XV Danube – European conference on geotechnical engineering |
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Paper n° 190 |
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1033-1038 |
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Brandl, H ; Adam, D |
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9-11 September - Vienna - Austria |
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EcoFoG @ carole.legrand @ |
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237 |
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Gérard, J. ; Guidal, D. ; Paradis, S. ; Cerre, J.C. ; Châlon, I. ; Thévenon, M.F. ; Thibaut, A. ; Brancheriau, L. ; Gandon, G. ; Guyot, A. ; Langbour, P. ; Lotte, S. ; Marchal, R. ; Martin, P. ; Thibaut, B. ; Vernay, M. ; Amusant, N. ; Baudassé, C. ; Boutahar, C. ; Cabantous, B. ; Gérard, C. ; Méjean, C. ; Mouras, S. ; Troalen, N. ; Vialle, M. ; Volle, G. ; Zaremski, A.; Baillères, H. ; Beauchêne, J. ; Boyer, F. ; Calchera, G. ; Candelier, K. ; Daigremont, C. ; Fouquet, D. ; Gallet, P. ; Koese, S. ; Leménager, N. ; Martin, L. ; Napoli, A. ; Pignolet, L. ; Pinta, F. ; Roda, J.M. ; Sales, C. ; Valière, P. |
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Title |
Atlas des bois tropicaux |
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Book Whole |
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2016 |
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999 |
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bois ; nomenclature ; identification ; anatomie du bois ; technologie du bois ; propriété technologique ; propriété physicochimique ; propriété mécanique ; utilisation ; préservation du bois ; sciage ; séchage ; monde ; bois tropical ; atlas ; fiche technique ; choix des bois |
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Quae |
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Français |
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Guide pratique : Quae |
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9782759225507 |
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EcoFoG @ carole.legrand @ |
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278 |
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Vidal-Sallé, E.; Aimène, Y.; Boisse, P. |
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Title |
Use of a hyperelastic constitutive law for dry woven forming simulations |
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2011 |
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AIP Conference Proceedings |
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AIP Conf. Proc. |
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1353 |
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883-888 |
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Composite; Forming; Hyperelastic; Numerical modelling |
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The increasing use of composite materials in industry implies an increasing use of automatic processes between which LCM processes take a large place. The improvement of such processes needs an extensive use of numerical simulations for all the stages of the process. In particular, it is necessary to know how the dry reinforcement is shaped. This paper presents a hyperelastic constitutive model for textile composite reinforcement at large strain based on an additive potential representative to tension and in-plane shearing. The proposed potential is a function of the right Cauchy Green and structural tensor invariants whose choice corresponds to textile composite reinforcement mechanical behaviour. The model is implemented in a user subroutine of ABAQUS/Explicit. The accuracy of the model has been checked and some simulations are performed on deep drawing with hemispheric punch. A good agreement is obtained with experimental forming experiments. © 2011 American Institute of Physics. |
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Université des Antilles et de la Guyane, Cayenne 97300, France |
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Belfast, United Kingdom |
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0094243x (Issn) |
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EsaForm 2011, 27–29 Avril 2011 |
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Export Date: 4 September 2013; Source: Scopus; doi: 10.1063/1.3589627; Language of Original Document: English; Correspondence Address: Laboratoire de Mécanique des Contacts et des Structures, UMR CNRS 52 59, Université de LyonFrance |
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EcoFoG @ webmaster @ |
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208 |
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