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| Author |
Houël, Emeline; Stien, Didier; Bourdy, Geneviève; Deharo, Eric |
| Title |
Chapter 161: Quassinoids: anticancer and antimalarial activities |
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Book Chapter |
| Year |
2013 |
Publication |
Handbook of Natural Products |
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3775 - 3802 |
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Quassinoids were initially isolated as bitter principles of plants of the Simaroubaceae family. These natural products are formed by oxidative degradation of triterpene derivatives. Since the 1970s, these molecules have attracted attention because of their promising biological activities, especially in the context of research regarding active anticancer and antimalarial principles. In this chapter, the structural diversity of quassinoids and their botanical and geographical occurrence are described, combining a historical perspective from the literature references regarding these two major biological activities and focusing on the results obtained in vivo with the most promising compounds; in vitro studies are less relevant and have already been extensively reviewed in the literature. The biological activities with respect to the uses of the corresponding Simaroubaceae in traditional medicine are also analyzed. |
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Springer-Verlag |
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Berlin Heidelberg |
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Ramawat, Kishan Gopal; Merillon, Jean-Michel |
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EcoFoG @ webmaster @ |
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164 |
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| Author |
Kanguem, J.N.; Robert, F.; Roos, C. |
| Title |
Biocorrosion of stainless steel 254 SMO by Amazonians microorganisms |
Type |
Conference Article |
| Year |
2011 |
Publication |
European Corrosion Congress 2011, EUROCORR 2011 |
Abbreviated Journal |
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| Volume |
4 |
Issue |
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Pages |
3373 |
| Keywords |
Bio corrosion; Bio film; Electrochemical techniques; Stainless steel |
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Corrosion induced by the microorganisms is a phenomenon still poorly known and difficult to interpret. In this work we are interested in marine corrosion of stainless steel 254 SMO by Amazonians biofilms. The objective is to achieve an experimental laboratory to reproduce the corrosion completely controlled environment. The microbiologically influenced corrosion (MIC) of stainless steel by marine bacteria was investigated using surface analysis (scanning electron microscopy (SEM)), and electrochemical techniques (the open circuit potential, electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization curves). The epifluorescence microscopy has been used to correlate the experiments. We investigated the role of some chemical parameters and the influence of the tide. |
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Laboratoire des Materiaux et Molecules en Milieu Amazonien, UAG-UMR ECOFOG, Campus Trou Biran, Cayenne 97337, French Guiana |
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Stockholm |
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9781618394125 (Isbn) |
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4-8 septembre 2011 |
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Export Date: 23 May 2012; Source: Scopus; Language of Original Document: English; Correspondence Address: Kanauem, J.N.; Laboratoire des Materiaux et Molecules en Milieu Amazonien, UAG-UMR ECOFOG, Campus Trou Biran, Cayenne 97337, French Guiana; email: christophe.roos@guyane.univ-ag.fr |
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EcoFoG @ webmaster @ |
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21 |
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Houel, E.; Bertani, S.; Bourdy, G.; Deharo, E.; Jullian, V.; Valentin, A.; Chevalley, S.; Stien, D. |
| Title |
Quassinoid constituents of Quassia amara L. (Simaroubaceae) leaf herbal tea. Impact on its antimalarial activity and cytotoxicity |
Type |
Conference Article |
| Year |
2010 |
Publication |
Planta Medica |
Abbreviated Journal |
Planta Med. |
| Volume |
76 |
Issue |
12 |
Pages |
1381-1382 |
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French Guiana records high malaria incidence rates. The traditional antimalarial remedy most widespread and still very much in use there is a tea made out from Quassia amara mature leaves. The antimalarial activity of this preparation was assessed [1] and in order to optimize the in vitro activity, different types of preparation have been realized and tested. The most active in vitro preparation is an infusion of fresh young leaves. It demonstrated a very good activity, in vitro as well as in vivo [2]. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10 nM against FcB1 Plasmodium falciparum chloroquine resistant strain in vitro [3]. Our next objective was to assess whether it could be contemplated to recommend this young leaves tea for treatment against malaria, since it seemed from literature precedent that SkD was also cytotoxic to a number of cellular lineages [4,5]. We then characterized and quantified the antiparasitic and cytotoxic activities of all the constituents. Several quassinoids were isolated and characterized in the tea: SkD, quassin, neoquassin, and picrasins B, H, I (new) and J (new), SkD being responsible of both antiplasmodial activity and cytotoxicity. In addition, in the context of an antimalarial treatment, it appeared that the dose necessary for obtaining a curative antimalarial effect is close to the toxic dose of an SkD analogue, bruceantin. Prior to emitting a definitive conclusion, a clinical study in humans similar to the one done with bruceantin [6] should be performed. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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no |
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EcoFoG @ webmaster @ |
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175 |
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Odonne, G.; Stien, D.; Bourdy, G. |
| Title |
Two piptocarphols from Pseudoelephantopus spicatus (Asteraceae) may explain its traditional use against cutaneous leishmaniasis amongst the Chayahuita (Peruvian Amerindians) |
Type |
Conference Article |
| Year |
2010 |
Publication |
Planta Medica |
Abbreviated Journal |
Planta Med. |
| Volume |
76 |
Issue |
12 |
Pages |
1381 |
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Chayahuita Amerindians are dwelling in north-west Peruvian Amazon. As they live in an endemic area of cutaneous and muco-cutaneous leishmaniasis, they developed a rich pharmacopoeia against those well recognized diseases [1]. Pseudoelephantopus spicatus (B. Juss. ex Aubl.) Rohr ex Gleason (Asteraceae) is one of the most used Chayahuita remedies against cutaneous leishmaniasis. In the course of evaluating those remedies against in vitro axenic amastigotes of Leishmania amazonensis, P. spicatus extract was found to be very active. Bioguided fractionation led to 3 active compounds (8,13-O-diacetyl-piptocarphol (1), 8-O-acetyl-13-O-ethyl-piptocarphol (2) and ursolic acid. Although these compounds had already been identified in other plants of the Vernoniae tribe (P. spicatus tribe) [2,3], none of them had been isolated from this species. 1 and 2 were found to be more active than amphotericin B against the parasite (IC50 for 1: 0.08±0.04µg/mL, 2: 0.14±0.05mg/mL, and 0.38µg/mL for amphotericin B), explaining at least partially the use of P. spicatus based remedies. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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no |
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EcoFoG @ webmaster @ |
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179 |
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Royer, M.; Herbette, G.; Eparvier, V.; Beauchêne, J.; Thibaut, B.; Stien, D. |
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Secondary metabolites of Bagassa guianensis Aubl. wood, a contribution to the understanding of the natural durability and to the chemotaxonomy of the Moraceae family with an unexplored genus |
Type |
Conference Article |
| Year |
2010 |
Publication |
Planta Medica |
Abbreviated Journal |
Planta Med. |
| Volume |
76 |
Issue |
12 |
Pages |
1375 |
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In effort to explain wood durability of Moraceae plants family, a phytochemical study was undertaken on Bagassa guianensis. The phytochemical investigation of the ethyl acetate extract obtained from the heartwood led to the isolation of 18 secondary metabolites, including 6 moracins [the new 6-O-methyl-moracin M (3), 6-O-methyl -moracin N (4) and moracin Z (5); the known moracin M (1), moracin N (2) and moracin P (6)], 8 phenolic derivatives [the new (-)-epialboctalol (12), arachidin 4 (10) and the known alboctalol (11), trans-resveratrol (7), arachidin 2 (9), trans-oxyresveratrol (8) and artogomezianol (13)], the 3 known flavonoids steppogenin (14), katuranin (15), dihydromorin (16), the β-sitosterol (17) and the resorcinol (18). Comparison with literature data indicates that stilbenoids are presumably responsible for the natural resistance of the wood against fungi degradation. In addition, chemical composition points out that B. guianensis is closely related to Morus sp. in the phylogeny and should be placed within the Moreae s. s. tribe in the Moraceae family, accordingly to the latest Weiblen genoma-based classifications [1,2]. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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no |
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EcoFoG @ webmaster @ |
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182 |
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Dubois-Fernandez, P.; Oriot, H.; Coulombeix, C.; Cantalloube, H.; Ruault du Plessis, O.; Thuy Le Toan, Daniel S.; Chave, J.; Blanc, L.; Davidson, M.; Petit, M. |
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Tropisar : exploring the temporal behavior of P-band sar data |
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Conference Article |
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2010 |
Publication |
Proceedings of the 2010 IEEE International Geoscience and Remote Sensing Symposium Publication |
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1319-1322 |
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July 25, 2010 |
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no |
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EcoFoG @ webmaster @ |
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127 |
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Rodrigues, A.; Theodoro, P.; Basset, C.; Espindola, L.; Stien, D. |
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Bio-inspiration in the discovery of active natural products: an example with the search of antifungal agents inspired from long-lasting woods |
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Conference Article |
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2010 |
Publication |
Planta Medica |
Abbreviated Journal |
Planta Med. |
| Volume |
76 |
Issue |
12 |
Pages |
1293 |
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Plant natural products have been perfected through evolution with respect to their specific biological roles (defense, elicitor, and so on) and are, therefore, an excellent starting point in the search for new biologically active chemicals. Hence, despite the progressive abandonment of the exploration of naturally sourced bioactive substances by the pharmaceutical industry, more than half of the drugs approved in the United States between 2005 and 2007 are natural products or natural product-derived drugs, five of which constituted the first members of new drug classes [1]. Clearly, chemical research into natural substances still has an important role to play in improving quality of life, and can play an important role by inventing innovative strategies to discover new bioactive compounds [1,2].
In the present work, we demonstrated that a bio-inspired approach for the identification of novel bioactive natural products represents a promising biotechnological tool for the development of new drugs. We have studied how natural defenses within decay-resistant wood can generate a large number of positive hits in the search for antimycotic agents. In addition, it was found from bioguided fractionation that ethyl acetate extracts of Sextonia rubra wood contain a relatively large proportion of antifungal metabolites rubrenolide (1) and rubrynolide (2), 1 being slightly more active than 2. The therapeutic potential of the above compounds will be discussed through the evaluation of their antifungal activities against 16 pathogenic fungi strains and their cytotoxicities towards KB cells. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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no |
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EcoFoG @ webmaster @ |
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181 |
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Le Ven, J.; Eparvier, V.; Litaudon, M.; Gueritte, F. |
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Isolation of bioactive aporphinoid alkaloids in Oxandra asbecki (Annonaceae) |
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Conference Article |
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2010 |
Publication |
Planta Medica |
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Planta Med. |
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76 |
Issue |
12 |
Pages |
1287 |
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Since prehistoric times, humans beneficially used natural resources for their daylife needs. Plants are able to synthesize complex molecules and consequently have a unique chemical diversity. This is a source of inspiration for new drugs discovery. Dyrk1A kinase is a target used in research on Alzheimer's disease. Inhibition of this kinase is associated with treating symptoms of this disease [1,2]. In France, the annual number of new cases is 230 000. The prevalence is expected to double in industrialized countries and quadruple in developing countries in the coming decades. The development of a better diagnosis and treatment is essential. The Annonaceae is a large family of tropical plants that have been investigated intensively. There exist 38 species in Oxandra genus and Oxandra asbecki species in Venezuela and in primary forests of French Guiana. To the aim of discovering new bioactive plants from French Guiana, Oxandra asbecki was selected for phytochemical study because of its potent inhibition of DyrK1A kinase. Bioassay-directed fractionation of the ethyl acetate extract provided three bioactive alkaloids. We isolated three aporphinoid alkaloids and show for the first time an strong activity (with micromolar IC50) of Velutamin under two kinase: CDK1 and DyrK1A, and activity of Aristolactam AII on DyrK1A kinase. |
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58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September 2010 |
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no |
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EcoFoG @ webmaster @ |
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177 |
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Faustin, M.; Maciuk, A.; Lebrini, M.; Robert, F.; Roos, C.; Figadere, B. |
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Isolation of Geissospermum laeve alkaloids by pH-zone refining centrifugal partition chromatography for metal corrosion studies |
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Conference Article |
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2012 |
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Planta Medica |
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78 |
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11 |
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1270 |
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Control of metal corrosion is of technical, economical, environmental, and aesthetical importance. The use of corrosion inhibitors is one of the best options to protect metals and alloys from corrosion. The environmental toxicity of synthetic inhibitors has prompted the search for green compounds. Plant extracts have become important as an environmentally acceptable, readily available and renewable source for a wide range of biodegradable, heavy metals-free inhibitors. Among natural compounds, alkaloids have very high corrosion inhibition efficiency. An alkaloidic extract of Geissospermum laeve (Apocynaceae) has been fractionated by centrifugal partition chromatography using the pH-zone refining mode in order to investigate the effect of isolated alkaloids on C38 steel corrosion in HCl 1M. Indole alkaloids were identified by LC-MS, 1H and 13C NMR. |
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2012 International Congress on Natural Products Research, New York City, July 28- August 1, 2012 |
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EcoFoG @ webmaster @ |
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174 |
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Dumontet, V.; Litaudon, M.; Olivon, F.; Poullain, C.; Rasoanaivo, P.; Stien, D.; Eparvier, V.; Houel, E.; Fokialakis, N.; Halabalaki, M.; Skaltsounis, A.; Espinosa, A.; Olmedo, D.; Gupta, M.; Fouche, G.; Hamburger, M.; Sorgenfrei, O.; Breuninger, D.; Gueritte, F. |
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Evaluation of natural products as potential agrochemical agents with insecticide, fungicide and herbicide activities |
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Conference Article |
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2012 |
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Planta Medica |
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78 |
Issue |
11 |
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1226 |
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The present work aims to identify new promising plant sources, which could be exploited for their agrochemical properties. A total of 484 natural products from academic libraries were selected for screening against four fungal pathogens, five insects and two plants. On the basis of the hits founded and a literature survey, the flora of source countries (New Caledonia, French Guiana, Madagascar, Panama, South Africa and Greece) was analysed for plants containing the desired scaffolds. Lists of 1800 plant part samples were thus established. The plant parts collected generated 3600 extracts that are being evaluated. |
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2012 International Congress on Natural Products Research, New York City, July 28- August 1, 2012 |
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EcoFoG @ webmaster @ |
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172 |
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